中国比较医学杂志2011，Vol.21Issue(10)：156-161,156,7.DOI:10.3969/j.issn.1671.7856.2011.10.11.035
动物实验替代方法与21世纪毒性测试发展策略
Animal Alternative Methods and the Development of Strategy for Toxicity Testing in the Twenty-first Century
摘要
Abstract
Traditional toxicity testing is facing great challenging as increasing new chemicals and the implementation of "3R" principle. The development of toxicity testing is approaching a pivotal point where expensive and lengthy traditional in vivo animal tests are transformed to in vitro high-throughput alternative methods with quantitative parameters analysis and mechanistic exploration. Animal alternative methods are considered not only for the compliance of " 3 R" principle, but also for the demands and scientific requirements for the development of toxicology and social economy. The development and application of animal alternative methods have become an important direction of toxicity testing in the twenty-first century, and are gained increasingly wide support and regulatory acceptance with broad prospect and important value.关键词
3R原则/动物实验替代方法/毒性测试/整合策略/体外毒理学Key words
3R principle/Animal alternative method/Toxicity testing/ Integrated strategy/In vitro toxicology分类
医药卫生引用本文复制引用
郭家彬,彭双清..动物实验替代方法与21世纪毒性测试发展策略[J].中国比较医学杂志,2011,21(10):156-161,156,7.基金项目
国家“重大新药创制”科技重大专项(2009 ZX09501-034) （2009 ZX09501-034）
国家科技支撑计划“食品安全关键技术”(2006BAK02A02) （2006BAK02A02）
国家973计划(2011 CB503803) （2011 CB503803）
