中国比较医学杂志2011，Vol.21Issue(10)：136-140,5.DOI:10.3969/j.issn.1671.7856.2011.10.11.031
小鼠胶原诱导性关节炎模型的建立及其免疫学变化研究
Establishment and Immunological Evaluation of Mouse Model of Collagen Induced Arthritis
摘要
Abstract
augmented spleen lymphocyte proliferation reaction to collagen II. At the same time, multiple cytokine levels in the supernatant of cultured spleen lymphocytes increased than control, such as IFN--γ, TNF-α and IL-1β. In addition, there was high amount collagen II-specific antibodie in the serum of CIA mice. Conclusions CIA mice characterized by abnormal activation of T cell, especially Th1 cell, with a high incidence, is a suitable RA model.关键词
CIA/细胞免疫/Th1/Th2/细胞因子Key words
Collagen induced arthritis/Cellular immunity/Thl/Th2/ Cytokine分类
医药卫生引用本文复制引用
肖智勇,张令令,张小锐,周文霞,张永祥..小鼠胶原诱导性关节炎模型的建立及其免疫学变化研究[J].中国比较医学杂志,2011,21(10):136-140,5.基金项目
国家“重大新药创制”科技重大专项(2009ZX09103-018,2009ZX09103-361) （2009ZX09103-018,2009ZX09103-361）
国家自然科学基金项目(81001652). （81001652）
