摘要
Abstract
AIM To observe the influence of allopurinol on the blood pressure in elderly patients with hyper-uricemia and to investigate its mechanism. METHODS A total of 105 elderly patients with essential hyperuricemia and hypertention were involved into this study. A total of 56 patients were in allopurinol group, given allopurinol 100 mg,bid in addition to a low-purine diet for 12 weeks; another 49 patients were in control group, with a low-purine diet for 12 weeks. Clinical blood pressure, fasting blood glucose, triglyceride, total cholesterol, creatinine, urea nitrogen, high-sensitivity C-reactive protein(hsCRP), uric acid, renin, AngⅡ and liver function were measured at baseline and at the end of study, and the adverse drug reactions were also observed. RESULTS The level of uric acid, clinical blood pressure, hsCRP, renin and AngⅡ were decreased after 12 weeks in allopurinol group compared with baseline( P < 0.01). Control group had no changes except the level of uric acid (P < 0.05). The damage of liver occurred in one patient, and the skin rash in another. CONCLUSION Allopurinol can reduce the level of uric acid as well as blood pressure in the elderly patients with essential hyperuricemia and hypertension.关键词
别嘌呤醇/老年/高尿酸血症/血压Key words
allopurinol/elderly/ hyperuricemia/blood pressure
