中山大学学报（医学科学版）2011，Vol.32Issue(6)：758-763,6.
人乳头瘤病毒基因型在宫颈癌、癌前病变及正常宫颈妇女中的分布
Human Papillomavirus Type Distribution in Women with and without Cervical Lesion
摘要
Abstract
[Objective]To survey the prevalence of human papillomavirus (HPV) and the type distribution in the women with and without cervical lesion from Guangzhou city. [Methods]The women who anticipated cervical cancer screening with normal cytology were grouped as normal LCT group, histologically confirmed cervical intraepithelial neoplasm grade I (CIN 1) as low-grade intraepithelial lesion (LSIL), CIN2-3 as high-grade intraepithelial lesion (HSIL) and invasive cervical cancer as ICC. Samples were detected by flow-through rapid hybridization. The set had a capacity of detecting 21 genotypes including high-risk HPVs (13 subtypes including HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68), low-risk HPVs (5 subtypes including HPV-6, 11, 42, 43, and 44) , and other types (3 subtypes including HPV-53, 66, and cp8304). [Results]A total of 971, 86, 286, and 97 women with normal cytology, with CIN 1, with CIN 2-3, and with ICC were enrolled, respectively. Overall HPV prevalences were 9.6%, 62.1%, 82.3%, and 90.2%, respectively, in women with normal cytology, with LSIL, with HSIL, and with ICC. High-risk HPV prevalences were 7.2%, 50.2%, 80.6%, and 87.4%; Low-risk HPV prevalences were 2.1%, 6.0%, 9.2%, and 5.4%; other HPVprevalences were 1.4%, 4.7%, 8.0%, and 8.5%. Stratified by cervical lesion grade, the five most common prevalent HPVs and type-specific prevalence were HPV-52 (2.7%), 16(1.3%); 31(1.2%), 58(1.1%), cp8304 (0.9%) in the women with normal cytology; 52(23.3%), 16(11.6%), 68(9.3%), 33(7.0%), and 53(7.0%) in the women with LSIL; 16(39.9%), 58(7.7%), 33(6.3%), 18(5.6%), and 52(4.9%) with HSIL; 16(52.6%), 18 (21.6%), 58(9.3%), 52(6.2%), cp8304(4.1%) with ICC. [Conclusion]Overall HPV prevalence in the women from Guangzhou with normal cytology, LSIL, HSIL, and ICC were similar to that reported in China and increased with severity of cervical lesion. But HPV-52 was the most predominant prevalence in the women with normal cytology and LSIL instead of HPV-16/18. HPV-16/18 turned to be predominant prevalence in the women with HSIL and ICC and may played important roll in progressing to ICC.关键词
宫颈/人乳头瘤病毒/型别分布Key words
cervix, human papillomavirus, type distribution分类
医药卫生引用本文复制引用
彭永排,张莘,陆晓楣,张丙忠,林仲秋..人乳头瘤病毒基因型在宫颈癌、癌前病变及正常宫颈妇女中的分布[J].中山大学学报（医学科学版）,2011,32(6):758-763,6.基金项目
国家自然科学基金(30872743) （30872743）
