中山大学学报（医学科学版）2011，Vol.32Issue(6)：713-718,6.
肝癌生长因子与血管内皮生长因子在肺癌患者血清和组织中的表达及意义
Expression of Hepatoma-derived Growth Factor and Vascular Endothelial Growth Factor in Serum or Tissues of Patients with Lung Cancer
摘要
Abstract
[Objective] The purpose of this study was to determine the changes and significance of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) in serum and lung tissue from patients with lung cancer. [Methods] Fifty-six new inpatients diagnosed with lung cancer were enrolled as the study group, fourteen patients with benign pulmonary diseases and fourteen healthy volunteers were selected for control groups. The levels of HDGF and VEGF in serum of all subjects were detected by ELISA,and the HDGF and VEGF expression in lung cancer tissues and adjacent normal lung tissues were detected by immunohistochemical assay. [Results] Patients with squamous cell lung cancer had higher HDGF levels in their serum than those patients with adenocarcinoma did (P < 0.01). Patients with undifferentiated and poorly differentiated lung cancer had higher HDGF levels in serum than those patients with mediate and well differentiated lung cancer did (P < 0.01).Patients with NSCLC in stages II-IV had higher levels of HDGF and VEGF in serum than patients with stage I disease did (P < 0.05). Lung cancer patients with lymph node metastasis had higher VEGF levels in serum than patients without lymph node metastasis did (P < 0.05). There was a positive correlation between VEGF and HDGF levels in serum from the patients with lung cancer (r = 0.35 ,P < 0.01). Both HDGF and VEGF expression were dramatically increased in lung tumor tissues compared with adjacent normal lung tissues (P < 0.01 ,P < 0.05).There was a positive correlation between the VEGF and HDGF levels in primary lung tumor tissues (r = 0.75,P < 0.05). [Conclusions] HDGF and VEGF play an important role in tumor growth and metastasis and there is a relationship between the two factors.关键词
肺癌/肝癌衍生生长因子/血管内皮生长因子/酶联免疫吸附法/免疫组织化学法Key words
lung cancer, hepatoma-derived growth factor, vascular endothelial growth factor, immunohistochemistry, ELISA分类
医药卫生引用本文复制引用
谭潇琼,周燕斌,黎银焕,黄琬玲,蔡兴东,曾庆理..肝癌生长因子与血管内皮生长因子在肺癌患者血清和组织中的表达及意义[J].中山大学学报（医学科学版）,2011,32(6):713-718,6.基金项目
国家自然科学基金(81071931) （81071931）
教育部回国人员科研启动基金(教外司留2010-609) （教外司留2010-609）
