中国药房2011，Vol.22Issue(45)：4255-4257,3.
罗哌卡因/乳酸羟基乙酸共聚物微球的小鼠组织生物相容性研究
Tissue Biocompatibility Study of Ropivacaine/Poly (lactide-co-glycolide) Microspheres in Mice
田洪居 1陈仲清 2刘玲玲 1刘桂林1
作者信息
- 1. 福建厦门市第二医院麻醉科,厦门市361026
- 2. 南方医科大学附属南方医院,广州市510515
- 折叠
摘要
Abstract
OBJECTIVE: To study the biocompatibility of Ropivacaine/poly (lactide-co-glycolide) microspheres (RVP/PLGAMS) in mice in vivo. METHODS: 40 Kunming mice were randomly divide into group A and B. In group A, the sciatic nerve exposed by surgical incision, and sutured after injecting RVP; in group B, the sciatic nerve exposed by surgical incision, and implanted with RVP/PLGA-MS, then sutured (0.48 to 0.5 mg of RVP). The inflammatory reaction, exudation and healing time of operative incision were observed. One week later, body weight of mice was compared between 2 groups. Mice were sacrificed after 2 weeks. The pathological changes of major organs in group B and local tissue slice of 2 groups were observed under light microscope. RESULTS: There was no statistical difference in incision healing and body weight between 2 groups. No significant pathological changes were found in local tissue slices of 2 groups. There were no pathological changes of major organs in group B. CONCLUSION: RVP/PLGA-MS in mice has a good biocompatibility in vivo.关键词
罗哌卡因/乳酸羟基乙酸共聚物微球/小鼠/局部组织/脏器/病理学/组织相容性Key words
Ropivacaine/poly (lactide-co-glycolide) microspheres/ Mice/ Local tissue/ Organs/ Pathology/ Biocompatibility分类
医药卫生引用本文复制引用
田洪居,陈仲清,刘玲玲,刘桂林..罗哌卡因/乳酸羟基乙酸共聚物微球的小鼠组织生物相容性研究[J].中国药房,2011,22(45):4255-4257,3.
