中国药房2011，Vol.22Issue(45)：4265-4268,4.
利用固体分散体技术改善吴茱萸次碱体外溶出度研究
Improvement of in Vitro Dissolution Rate of Rutaecarpine Using Solid Dispersion Technology
邝少轶 1闫美玲 2丁劲松 2高瑞 2李元建 2周彦彬2
作者信息
- 1. 海南医学院,海口市571101
- 2. 中南大学药学院,长沙市410013
- 折叠
摘要
Abstract
OBJECTIVE: To prepare rutaecarpine (Rut) solid dispersion (SD), and to improve the dissolution rate of rutaecarpine in vitro. METHODS: Rut-SD containing different supplementary carriers (gum arabic, lactose, avicel, chenic acid, lecithin, talcum, etc.) with different ratios was prepared by solvent-melting method using PVP as carrier. The dissolution rate in vitro was evaluted and the formula was optimized. Differential thermal analysis and X-ray diffraction were used for phase identification of SD. RESULTS: The optimal formula included Rut-PVP-gum arabic (1:2:1) and Rut-PVP-lactose (1:2:2). The accumulative dissolution rate of them (60 min) was improved about 6 times as physical mixture with same component. Phase identification indicated that Rut existed in the form of microcrystal in SD. CONCLUSION: Rut-SD can improve in vitro dissolution rate of Rut which has been prepared with PVP as carrier and using suitable ratio of gum arabic and lactose as supplementary carrier.关键词
吴莱萸次碱/固体分散体/聚乙烯吡咯烷酮/体外溶出度Key words
Rutaecarpine/ Solid dispersion/ PVP/ Dissolution rate in vitro分类
医药卫生引用本文复制引用
邝少轶,闫美玲,丁劲松,高瑞,李元建,周彦彬..利用固体分散体技术改善吴茱萸次碱体外溶出度研究[J].中国药房,2011,22(45):4265-4268,4.
