西安交通大学学报（医学版）2011，Vol.32Issue(5)：615-618,4.
乙型肝炎病毒x蛋白在HBV宫内感染中的作用
Role of hepatitis B virus x protein in intrauterine infection
摘要
Abstract
Objective To study the difference of hepatitis B x antigen (HBxAg) expression level in hepatitis B virus (HBV)-infected placenta and normal placenta and then discuss the possible role of HBxAg in intrauterine infection. Methods We selected 24 full-term pregnant women who had been verified with intrauterine infection [hepatitis B surface antigen (HBsAg) positive] as the infected group and 10 normal full-term pregnant women as the control group. We used immunohistochemical staining method (SP staining method) to test the expression of HBxAg in trophoblastic cells and TUNEL method to detect apoptosis level. Results There was HBxAg expression in HBV-infected placenta; and the optical-density value in the high copy group (HBV-DNA copy level >1 × 103 copy/ mL) was significantly higher than that in the low copy group (HBV-DNA copy level <1 × 103 copy/mL) (P< 0.05). TUNEL results showed that the apoptosis index was obviously higher in the normal group and the low copy group than in the high copy group (P<0.01). Conclusion HBxAg/antiapoptotic action in full-term pregnant women who have been infected by high level of HBV-DNA is a possible mechanism of intrauterine infection; and the pregnant women with negative HBV-DNA have different mechanisms.关键词
乙型肝炎病毒x蛋白(HBxAg)/细胞凋亡/官内感染Key words
hepatitis B x antigen (HbxAg)/cell apoptosis/intrauterine infection分类
医药卫生引用本文复制引用
白桂芹,张凌燕,付逢萍,唐瑶..乙型肝炎病毒x蛋白在HBV宫内感染中的作用[J].西安交通大学学报（医学版）,2011,32(5):615-618,4.基金项目
国家自然科学基金资助项目(No.30872220) （No.30872220）
