北京中医药大学学报2011，Vol.34Issue(11)：746-750,5.
益气养阴消癥通络中药对早期糖尿病大鼠肾脏的保护作用及其相关机制
Protective effect on kidney and mechanism of Chinese medicinal with actions of replenishing qi, nourishing yin, removing accumulation and free collateral vessels in rats with early diabetes
摘要
Abstract
Objective To investigate the protective effect of Chinese medicinal with the actions of replenishing qi, nourishing yin, removing accumulation and free collateral vessels on kidney in rats with early diabetes, and discuss possible molecular biology mechanism. Methods SD rats were randomly divided into the nephrectomy group, model group, irbesartan group, high-dose, mid-dose and low dose Chinese medicinal groups (high-dose group, mid-dose group and low-dose group). All groups were given relevant medicinal intragastrically. At the end of the 6th week the levels of 24-hour urinary protein (U Pro) and renal function were detected in rats of all groups. The pathological changes of kidney were observed with light microscope. The protein expressions of p38MAPK, p-p38MAPK, STAT3 and p-STAT3 in renal cortex were detected by using Western blotting method. Results The level of U Pro and protein expressions of p-p38MAPK and p-STAT3 decreased significantly in the irbesatan group, low-dose group and mid-dose group compared with the model group (P ＜0. 05). The renal function was improved and the pathological changes were relieved in all treatment groups compared with the model group (P ＜ 0.05). Conclusion The inhibition of activation of p38MAPK/STAT3 signal transmission pathway may be one of kidney-protecting mechanisms of Chinese medicinal with the actions of replenishing qi, nourishing yin, removing accumulation and free collateral vessels in rats with early diabetes.关键词
益气养阴消癥通络中药/糖尿病肾病/作用机制/大鼠Key words
Chinese medicinal with the actions of replenishing qi, nourishing yin/ removing accumulation and free collateral vessels/ diabetic nephropathy/ mechanism of action/ rats分类
医药卫生引用本文复制引用
陈志强,赵雯红,张江华,孙玉凤,王月华..益气养阴消癥通络中药对早期糖尿病大鼠肾脏的保护作用及其相关机制[J].北京中医药大学学报,2011,34(11):746-750,5.基金项目
河北省自然科学基金资助项目(No.C2008001074),河北省卫生厅资助项目(No.08165),河北省科学研究与发展计划项目(No.09276101 D-27) （No.C2008001074）
