中国美容医学2011，Vol.20Issue(12)：1912-1915,4.
MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达及意义
Expressions and significances of MP-2, MMP-9, TIMP-2, TIMP-1 in skin basal cell carcinoma and squamous cell carcinoma
黄静仪 1刘林蟠 1张建文1
作者信息
- 1. 郑州大学第一附属医院 整形外科 河南 郑州 450052
- 折叠
摘要
Abstract
Objective To investigate the expressions and significances of matrix metalloproteinase-2 (MMP-2),matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2),tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) protein in skin basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Methods Twenty six patients with SCC and twenty two patients with BCC.confirmed by pathology.were selected. Immunohistochemistry of tissues were performed using SABC method. Expression rate.staining intensity and expression intensity of every factor were recorded. Meanwhile,20 normal skin was selected as control. The results were compared between the groups. Results Compared with control group, expression rate.staining intensity and expression intensity of MMP-2, MMP-9 in SCC and BCC groups were significantly higher,TIMP-2,TIMP-1 in SCC and BCC groups were significantly lower (P<0.05). Expression intensity of MMP-2.MMP-9 in SCC group were higher than those in BCC group, TIMP-2.TIMP-1 in SCC group were lower than those in BCC group(P<0.05). Conclusion MMP-2.MMP-9 and TIMP-2.TIMP-1 may play an important role in development, progression,invasion and metastasis of SCC and BCC.关键词
基质金属蛋白酶/基质金属蛋白酶组织抑制物/非黑色素性皮肤癌/表达Key words
Matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase/non-melaoma skin cancer/expression分类
生物科学引用本文复制引用
黄静仪,刘林蟠,张建文..MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达及意义[J].中国美容医学,2011,20(12):1912-1915,4.
