中国动脉硬化杂志2011，Vol.19Issue(12)：979-983,5.
阿托伐他汀对动脉粥样硬化兔氧化应激/炎症反应的影响
Effect of Atorvastatin on Oxidative Stress/Inflammatory Response in Rabbits with Atherosclerosis
摘要
Abstract
Aim To study the non-lipid mechanisms of atorvastatin treating atherosclerosis by observing thechanges of oxidative stress and inflammatory response. Methods The rabbit model of atherosclerosis were prepared by feeding the high fat diet and immune stimulation, then 0.435 mg/( kg·d) suspension of atorvastatin was given for 1 month. It was observed for the rabbit serum superoxide dismutase ( SOD) activity, malondialdehyde ( MDA) and oxidized low density lipoprotein (ox-LDL) levels and lectin-like oxidized low density lipoprotein cholesterol receptor-1 (LOX-1) , vascular cell adhesion molecule-1 (VCAM-1) , intercellular adhesion molecule-1 (ICAM-1) , monocyte chemoattrac-tant protein-1 (MCP-1) gene and protein expression. Results Compared with the control group, rabbit serum SOD activity was significantly decreased ( P < 0. 01) , serum MDA, ox-LDL was significantly higher ( P < 0. 01) ; mRNA and protein expression of aortic LOX-1, VCAM-1, ICAM-1, and MCP-1 were significantly increased (P <0. 05 or P <0. 01) in atherosclerosis model group. Compared with model group, rabbits serum SOD activity was significantly increased ( P < 0. 01) , serum MDA, ox-LDL levels were significantly decreased (P < 0. 01 ) ; mRNA and protein expression of aortic LOX-1, VCAM-1, ICAM-1, and MCP-1 were significantly lower in atorvastatin group (P < 0. 05 or P < 0. 01). Conclusions Atorvastatin possesses anti-oxidative stress and inflammatory response, thereby it can protect the vascular endothelium and play a therapeutic role in atherosclerosis.关键词
动脉粥样硬化/氧化应激/超氧化物歧化酶/丙二醛/氧化型低密度脂蛋白/血管细胞黏附分子1/细胞间黏附分子1/单核细胞趋化蛋白1Key words
Atherosclerosis/Oxidative Stress/Superoxide Dismutase/Malondialdehyde/Oxidized LowDensity Lipoprotein/Vascular Cell Adhesion Molecule-1/Intercellular Adhesion Molecule-1/Monocyte Chemoattractant Protein-1分类
医药卫生引用本文复制引用
葛金文,刘吉勇,朱惠斌,陈懿,王国佐..阿托伐他汀对动脉粥样硬化兔氧化应激/炎症反应的影响[J].中国动脉硬化杂志,2011,19(12):979-983,5.基金项目
湖南省自然科学基金重点课题(09JJ3073) （09JJ3073）
长沙市科技计划重点项目(K0802106-31) （K0802106-31）
