高等学校化学学报2011，Vol.32Issue(10)：2453-2459,7.
组分对含羟基磷灰石/脂肪族聚氨酯复合骨组织工程支架的理化性能及生物学性能的影响
Effect of Composition on Physical-chemical Properties and Biological Properties of Hydroxyapatite/Aliphatic Polyurethane Scaffolds for Bone Tissue Engineering
摘要
Abstract
Aliphatic polyurethane(PU) and hydroxyapatite(HA) composite scaffolds were prepared by in-situ polymerization and gas self-foaming process. The morphologies and properties of the scaffolds were studied by varying the contents of HA, foaming agent (water) and soft/hard segment ratio and characterized by scanning electron microscope ( SEM), X-ray diffraction ( XRD), Fourier transform infrared spectroscopy (FTIR) and mechanical test. The results show that the compressive strength of the scaffolds increased with both the HA contents and the hard segment contents. The scaffold porous structure was affected by HA content and foaming agent. The scaffold porosity increased with HA contents and decreased with the hard segment contents. The average pore size of the scaffold also was increased with the contents of foaming agent. MTT results and SEM observation of cells showed that the porous structure of HA/PU scaffold provides a good microenvironment for cell adherence, growth and proliferation. After implantation in rat muscle, the scaffold was well tolerated by host tissues. The porous HA/PU scaffold provides a good perspective for designable tissue-engineering scaffolds.关键词
骨组织工程支架/羟基磷灰石/脂肪族聚氨酯/组分影响/生物学性能Key words
Bone tissue engineering scaffold/ Hydroxyapatite/ Aliphatic polyurethane/ Effect of composition/Biological property分类
化学化工引用本文复制引用
王立,左奕,邹琴,李玉宝..组分对含羟基磷灰石/脂肪族聚氨酯复合骨组织工程支架的理化性能及生物学性能的影响[J].高等学校化学学报,2011,32(10):2453-2459,7.基金项目
国家“九七三”计划项目(批准号:2007CB936102) （批准号:2007CB936102）
国际科技合作和与交流专项(中荷战略联盟项目)(批准号:2008DFB50120)和国家自然科学基金(批准号:50972096)资助. （中荷战略联盟项目）
