武警医学2011，Vol.22Issue(11)：973-975,978,4.
塞莱昔布对乳腺癌大鼠肝肾功能的影响
Effect of celecoxib on hepatic and renal functions in rats with mammary carcinoma
摘要
Abstract
Objective To evaluate the effect of celecoxib, a selective cyclooxygenase -2 inhibitor, on the hepatic and renal functions of rats with chemically induced mammary carcinoma. Methods A single dose of 7,12 dimethgylbenz anthracene was administered I. G. Into female SD rats to induce mammary carcinoma, during which celecoxib was given at various doses. Hepatic and renal functions were determined and statistically analyzed in rats receiving various doses of celecoxib. Results Four weeks into the experiment , hepatic and renal functions in none of the groups were significantly different. The same was true of hepatic functions on week 17 , when serum creatinine levels in 100 mg/kg and 150 mg/kg celecoxib groups were significantly different, compared with those in model control group (P <0. 01). However, the serum creatinine level in 50 mg/kg celecoxib group was not significantly different from that in model control group (P > 0. 05). Conclusions Prophylactic administration of celecoxib in rats with DMBA - induced breast tumors is safe, though prolonged administration of celecoxib at high doses results in impaired renal function. Further studies are required to validate its safety profiles in clinical application.关键词
塞莱昔布/DMBA/乳腺肿瘤/大鼠/肝肾功能Key words
celecoxib/ 7,12 dimethlbenz anthracene/ mammary tumor/ rats/ hepatic and renal functions分类
医药卫生引用本文复制引用
姚雨石,钱跃清,于忠和..塞莱昔布对乳腺癌大鼠肝肾功能的影响[J].武警医学,2011,22(11):973-975,978,4.基金项目
首都医学科学发展基金(2002-3025) （2002-3025）
