高等学校化学学报2011，Vol.32Issue(10)：2437-2440,4.
高强度聚乙烯醇水凝胶微球的制备
Preparation of Polyvinyl Alcohol Hydrogel Microspheres with High Strength
摘要
Abstract
Physical cross-linked poly vinyl alcohol (PV A) hydrogel microspheres with high strength were prepared by a modified high-voltage electrostatic technique. The hydrogel microspheres were solidified and suspended in coagulation liquid composed of chloroform and acetone, then the microspheres in coagulation liquid were frozen and thawed to get PVA cross-linked. The influence factors of PVA microspheres' diameter and morphology, such as, coagulation liquid, PVA solution concentration and flow rate, temperature and humidity and electrostatic field strength of high-voltage electrostatic system, the number of froze and thaw cycle of PVA were investigated. The results showed that high-voltage electrostatic system modified with atmospheric steam to control temperature and humidity of PVA microsphere formation area was an effective method to overcome mi-crofilament formation while PVA solution was in higher concentration, the optimized condition for prepare PVA hydrogel microspheres with high strength and controlled diameter was coagulation liquid of chloroform/acetone (2:1, volume ratio) , frozen at -20 ℃ and thawed at room temperature for five cycles, PVA solution concentration of 12% in weight, flow rate of 2 mL/h, electrostatic field strength of 12-15 kV, electrode distance of 3 cm, and the PVA hydrogel microsphere has a widely potential use in the field of tissue engineering.关键词
高压静电法/物理交联/聚乙烯醇水凝胶微球/组织工程Key words
High-voltage electrostatic/ Physical cross-linking/ Polyvingl alchol(PVA) hydrogel microsphere/ Tissue engineering分类
化学化工引用本文复制引用
高素照,陈际达,亓倩倩,舒荣德,邱智萍,任竞争..高强度聚乙烯醇水凝胶微球的制备[J].高等学校化学学报,2011,32(10):2437-2440,4.基金项目
重庆市自然科学基金(批准号:CSTC2008BB4056)和重庆大学211工程三期创新人才培养计划建设项目(批准号:S-09103)资助. （批准号:CSTC2008BB4056）
