高等学校化学学报2011，Vol.32Issue(11)：2515-2520,6.
基于选择离子集成谱的中药质量评价新方法
Novel Approach for Quality Evaluation of Traditional Chinese Medicine Based on Integrated Selected-ion Chromatograms
摘要
Abstract
A liquid chromatography-mass spectrometry(LC-MS) based fingerprinting method was developed to study the Shuangdan extracts prepared by Danshen and Danpi from different habits; the two-way LC-MS data sets were converted to one-way integrated selected-ion chromatograms (ISICs) by our homely-made software and their discriminate power together with total ion chromatograms (TICs) and retention time corrected TICs were evaluated by principle component analysis. The results showed that ISICs surpassed TICs and retention time corrected TICs to separate herbal extracts from different places of produce. This transformation approach is rather fast and compatible with large datasets. The ISICs having more chemical information than TICs could be directly exported to statistical softwares for further analysis, whose retention times do not need to be correc ted.关键词
选择离子集成谱/双丹方/液相色谱-质谱联用技术Key words
Integrated selected-ion chromatogram ( ISIC ) / Shuangdan formula/ Liquid chromatography-mass spectrometry( LC-MS)分类
化学化工引用本文复制引用
张玉峰,范骁辉,瞿海斌..基于选择离子集成谱的中药质量评价新方法[J].高等学校化学学报,2011,32(11):2515-2520,6.基金项目
国家重大科技专项“重大新药创制”项目(批准号:2009ZX09313-036,2009ZX09304-002)和国家自然科学基金(批准号:81001687)资助. （批准号:2009ZX09313-036,2009ZX09304-002）
