高等学校化学学报2011，Vol.32Issue(11)：2521-2527,7.
阳虚体质者血清和尿液的核磁共振代谢组学
NMR-based Metabonomics Studies on Serum and Urine of Yang-deficiency Constitution
摘要
Abstract
Nuclear magnetic resonance ( N MR)-based metabonomics was applied to study the yareg-deficiency constitution by analyzing metabolic profiling of serum and urine. The purpose of this study is to determine an array of characteristic metabolites in serum and urine samples from yang-deficiency constitution person and then to interpret these metabolites in possible metabolic pathway. Serum and urine samples from 30 yang-defi ciency constitution person with 30 balanced constitution person were collected. Differences in endogenous metabolites were detected on serum and urine samples from the yang-deficiency constitution group and control group using multivariate statistical analysis. Compared with the balanced constitution, the contents of lactate, very low density lipoprotein( VLDL)/low density lipoprotein ( LDL) , /V-cetyl glycoprotein ( Nac ) , fatty acid (FA) , unsaturated fatty acid (UFA) are lower while the contents of glutamine, glucose, phosphatidylcholine (PtdCho) , high density lipoprotein( HDL) are higher in serum of yarag-deficiency constitution, and the content of creatinine is lower while the contents of lactate, DMA, citrate, hippurate are higher in urine of yang-deficiency constitution. The biomarkers supply new ways for the individual differences from the point of view of metabonomics. Fang-deficiency constitution has some metabolism disorder of energy, lipid and glucose, and also has changes of organs functions.关键词
阳虚体质/核磁共振/代谢组学Key words
Yang-deficiency constitution/ Nuclear magnetic resonance(NMR) / Metabonomics分类
化学化工引用本文复制引用
李英帅,王琦,袁卓珺..阳虚体质者血清和尿液的核磁共振代谢组学[J].高等学校化学学报,2011,32(11):2521-2527,7.基金项目
国家自然科学基金(批准号:90709050)资助. （批准号:90709050）
