肿瘤防治研究2011，Vol.38Issue(11)：1280-1282,3.DOI:10.3971/j.issn.1000-8578.2011.11.016
ATP生物荧光技术指导大肠癌患者腹腔化疗的研究
ATP Bioluminescence Technical Guides Intra-peritoneal Chemotherapy in Patients with Colorectal Cancer
摘要
Abstract
Objective To evaluate the feasibility and efficacy of the intra-peritoneal chemotherapy guided by ATP biolu minescence tumor chemo-sensitivity assay for human colorectal cancer. Methods Thirty-two cases with the colorectal cancer malignant ascites were collected for ATP-TCA to deter mine the chemo-sensitivity. The drug with the highest inhibition rate was selected for intra-peritoneal chemotherapy. The results of ATP-TCA and the response of malignant ascites, the clinical features and Karnofsky performance score(KPS) were analyzed. Results There were considerable differences in chemo-sensitivity between individuals. Hydroxycamptothecin (HCPT) was the most effective to the colorectal cancer malignant ascites. Fifteen patients showed response by intra-peritoneal chemotherapy (complete response: 1, partial response: 14). The KPS of the responders was improved significantly. Conclusion In vitro chemo-sensitivity ATP biolu minescence tumor assay was safe and effective to guide intra-peritoneal chemotherapy for colorectal cancer malignant ascites, through improvement of the KPS.关键词
ATP-TCA/大肠癌/腹水Key words
ATP-TCA/ Human colorectal cancer/ Malignant ascites分类
医药卫生引用本文复制引用
周莉,侯安继..ATP生物荧光技术指导大肠癌患者腹腔化疗的研究[J].肿瘤防治研究,2011,38(11):1280-1282,3.基金项目
上海市浦东新区社发局优秀青年医学人才基金资助项目(PWRg2008-9) （PWRg2008-9）
