肿瘤防治研究2011，Vol.38Issue(11)：1296-1298,3.DOI:10.3971/j.issn.1000-8578.2011.11.020
替吉奥胶囊联合奈达铂及紫杉醇治疗远处转移鼻咽癌疗效观察
Clinical Efficacy of Compound Tegafur Capsule Plus Nedaplatin and Paclitaxel in Treatment of Patients with Distant Metastatic Nasopharyngeal Carcinoma
李远东 1吴灿 1余汉毅 1许晓峰 2黄壬峰2
作者信息
- 1. 512000广东韶关,广东医学院附属韶关医院肿瘤科
- 2. 512000广东韶关,广东医学院附属韶关医院放疗科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and toxicity Compound tegafur capsule(S-l) plus Nedapla-tin and Paclitaxel (SNP) regimen in the treatment of distant metastatic nasopharyngeal carcinoma. Methods Twenty-one patients with distant metastatic nasopharyngeal carcinoma were enrolled and treated with S-l capsule 80 mg/m2 twice daily for 14 days plus nedaplatin 80 mg/tn2 and paclitaxel 135 mg/m2 by intravenous drip on dl. Treatment was administered every 3 weeks for 2~4 cycles. Results The total effective rate was 71. 4%. Three cases were complete response(14. 3% ), 12 cases were partial response (57. 1 % ), 5 cases was stable disease (23. 8%), 1 case were progressing disease (4. 8%). The main adverse effect was myelosuppression, such as grade Ⅲ~- Ⅳ neutropenia in 71. 5% of all cases and grade Ⅱ ~Ⅲ thrombocytopenia in 52. 3% of all cases. Other adverse effects could be tolerated. Conclution SNP regimen was a safe and effective therapy for patients with metastatic nasopharyngeal carcinoma although the long-term effects still need further evaluatioa关键词
鼻咽肿瘤/替吉奥胶囊/奈达铂/紫杉醇Key words
Nasopharyngeal neoplasms/ Compound tegafur capsule/Nedaplatin/ Paclitaxel分类
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李远东,吴灿,余汉毅,许晓峰,黄壬峰..替吉奥胶囊联合奈达铂及紫杉醇治疗远处转移鼻咽癌疗效观察[J].肿瘤防治研究,2011,38(11):1296-1298,3.
