分析测试学报2011，Vol.30Issue(11)：1224-1229,6.DOI:10.3969/j.issn.1004-4957.2011.11.004
超顺磁纳米颗粒弛豫时间传感技术在生化分析中的研究进展
Research Progress on Magnetic Relaxation Switches Based on Superparamagnetic Nanoparticle and Their Applications in Biochemical Analysis
摘要
Abstract
The magnetic relaxation switches( MRS) technology based on superparamagnetic nanopar-ticles(SMP) and their applications in biochemical analysis were introduced in this paper. In homogenous magnetic field of miniaturized nuclear magnetic, the dispersed and aggregated states of SMP produce local inhomogeneities in the applied magnetic field, resulting in the decrease or increase in the spin ± spin relaxation time( T2) of surrounding water molecules, which is called magnetic relaxation time ( MRS) sensing effect. The magnetic particles binding with specific molecules can act as magnetic relaxation switches (MRS) when they coupled specially with target analytes. In MRS assays, the presence of an analyte causes the particles to transition between dispersed and clustered states and affects the T2 relaxation times of surrounding water molecules. Compared with the conventional immu-nological methods, MRS assay is more sensitive, simple and time-saving due to its combination of nanobiotechnology, nuclear magnetic resonance and immunoassay. Predictably, it has a remarkable application potential in the fields of medical diagnosis, environmental monitoring, food safety analysis, public healthy security and molecular interactions study, etc.关键词
超顺磁纳米颗粒/弛豫时间/纳米传感/生化分析Key words
superparamagnetic particle (SMP) / magnetic relaxation switches ( MRS) / nano biological sensing/ biochemical analysis分类
数理科学引用本文复制引用
陈翊平,邹明强,王大宁,谢孟峡,王燕飞,薛强,李锦丰..超顺磁纳米颗粒弛豫时间传感技术在生化分析中的研究进展[J].分析测试学报,2011,30(11):1224-1229,6.基金项目
国家自然科学基金资助项目(20875084) （20875084）
中国检验检疫科学研究院基本科研业务费资助项目(2010JK016) （2010JK016）
