中国畜牧杂志2011，Vol.47Issue(1)：41-44,4.
妊娠期添加叶酸对新生仔猪肝脏抗氧化能力和基因表达影响
Effects of Maternal Folic Acid Supplementation on Antioxidant Abilities and Gene Expression in Liver of Newborn Piglets
摘要
Abstract
Twenty-four gilts (Yorkshire) were randomly allotted to 2 groups with 12 replications to study the effects of maternal folic acid supplementation on hepatic antioxidant capacity and expression patterns of genes involved in folic acid metabolism in newborn piglets during gestation period. The control group was fed with basal diet (folic acid 1.3 mg/kg), which was the typical corn-soybean meal. Folic acid was added into the basal diet as the experimental group diet (folic acid 30 mg/ kg). The trial duration was last from mating to delivery. The results showed that maternal folic acid supplementation increased serum folic acid content of piglets (P < 0.01) and reduced serum homocysteine content (P < 0.01) significantly during the gestational period. Compared with the control group, the activities of hepatic T-AOC(P< 0.05),GSH-Px (P< 0.05) and SOD (P < 0.05) in piglets of experimental group were increased, but the concentrations of MDA and NO were reduced significantly (P < 0.05) after folic acid addition. Maternal folic acid supplementation increased the expression levels of cSHMT (P < 0.05) and decreased the mRNA levels of T-protein (P< 0.05). The results revealed that maternal folic acid supplementation could improve hepatic antioxidant capacity in piglets and altered expression patterns of genes involved in folic acid metabolism.关键词
叶酸/抗氧化/基因表达/母猪Key words
folic acid/ antioxidant/ gene expression/ gilts分类
畜牧业引用本文复制引用
刘静波,陈代文,余冰,姚英..妊娠期添加叶酸对新生仔猪肝脏抗氧化能力和基因表达影响[J].中国畜牧杂志,2011,47(1):41-44,4.基金项目
教育部创新团队研究项目(IRT0555-5) （IRT0555-5）
