医学分子生物学杂志2011，Vol.8Issue(6)：529-532,4.DOI:10.3870/j.issn.1672-8009.2011.06.013
基于纳米金的比色分析法在核酸检测中的应用
Application of Nanogold-Based Colorimetry in Nucleic Acid Detection
刘小兰 1徐克前1
作者信息
- 1. 中南大学湘雅医学院医学检验系,长沙市,410013
- 折叠
摘要
Abstract
With the development of nanotechnology, research of nanoparticle application in nucleic acid detection has become a hot topic. Among the nucleic acid detection methods, colorimetric detection based on gold nanoparticles ( nanogold ) is more clinically applicable, as it is easily per-formable by optical instruments, even with naked eyes. There are diverse nanogold-based colorimetric detection methods, which are different in sensibility and credibility. According to the modification by gold nanoparticles via oligonucleotide probes the nanogold-based colorimetric methods are classified into two types, modified and non-modified nanogold-based colorimetric detections. The former includes aggregation system by utilizing color change of gold nanoparticles and silver staining system by utilizing redox ability of gold nanoparticles.关键词
纳米金/比色法/核酸检测Key words
gold nanoparticles/ colorimetric detection/ nucleic acid分类
生物科学引用本文复制引用
刘小兰,徐克前..基于纳米金的比色分析法在核酸检测中的应用[J].医学分子生物学杂志,2011,8(6):529-532,4.
