中国中西医结合外科杂志2012，Vol.18Issue(1)：3-6,4.DOI:10.3969/j.issn.1007-6948.2012.01.001
芪黄煎剂对上消化道肿瘤术后血清促炎细胞因子及其mRNA表达的影响
Effect of Qihuang Decoction (芪黄煎剂) on Proinflammatory Cytokine and Its mRNA Expression in Postoperative Patients with Upper Gastrointestinal Tract Tumors
摘要
Abstract
Objective To observe the effect of Qihuang decoction (芪黄煎剂) on proinflammatory cytokines and its mRNA expression in postoperative patients with upper gastrointestinal tract tumor. Method Forty upper gastrointestinal tract tumor patients were randomized into the study group of 20 cases and the control group of 20 cases,patients in the study group were given Chinese herbs Qihuang decoction via the silicon catheters in-tubated into the small intestine on the first postoperative day for 7 days, while those patiens in the control group were given 0.9g/L normal saline. Serum levels of proinflammatory cytokines and its mRNA expression were detected postoperatively. Results Proinflammatory cytokines in serum of both groups significantly decreased (P＜0.05)on the first postoperative day,The serum proinflammatory cytokines levels of the study group significantly decreased on the 7th postoperative day as compared with those of the first postoperative day {P＜T 0.05). Proinflammatory cytokines of the study group significantly decreased on the 7th postoperative day (P ＜T 0.05). Conclusion Early application of Chinese herbs Qihuang decoction in postoperative patients with upper gastrointestinal tract tumor can promote proinflammatory cytokines (IL-lα,IL-6,TNF-α) mRNA expression, regulate pro-inflammatory cytokines in serum to normal levels, and play an important role in recovery of immune function and control of inflammatory response after upper gastrointestinal tract tumor operation.关键词
芪黄煎剂/上消化道肿瘤/促炎细胞因子/mRNA/手术后Key words
Qihuang decoction/upper gastrointestinal tract tumor/proinflammatory cytokines/mRNA/Postoperative Patients分类
医药卫生引用本文复制引用
王传思,于庆生,潘晋方,王汉明,张琦,刘举达..芪黄煎剂对上消化道肿瘤术后血清促炎细胞因子及其mRNA表达的影响[J].中国中西医结合外科杂志,2012,18(1):3-6,4.基金项目
2007年度安徽省科技攻关计划项目(07010300201) （07010300201）
安徽省人才基金项目(2006Z040) （2006Z040）
