中国中西医结合外科杂志2012，Vol.18Issue(1)：51-54,4.DOI:10.3969/j.issn.1007-6948.2012.01.015
胃旁路术对非肥胖型2型糖尿病大鼠糖代谢的影响
Effect of Gastric Bypass Surgery on Glucose Metabolism of Non-obese Type 2 Diabetes Mellitus in Goto-Kakizaki Rats
曹超 1周晓磊 2尤胜义2
作者信息
- 1. 天津医科大学研究生院,天津300070
- 2. 天津医科大学总医院中西医结合外科,天津300052
- 折叠
摘要
Abstract
Objective To investigate the influence of gastric bypass surgery on glucose metabolism in Goto- Kakizaki (GK) rats. Methods Twenty male GK rats and 10 male Wistar rats were randomized into 3 groups; GK operation, GK sham-operation and Wistar sham-operation groups, gastric bypass surgery was pro-cessed in the GK operation group . Body weight, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc) level and serum insulin (INS) were moni-tored at 1 week before surgery and at the 1st, 2nd, 4th, 8th and 12th week after surgery. Result In the GK operation group the weight increased from 255.10±21.09 g before surgery to 364.55±25.73 g, and the FPG decreased from 11.36±1.14 mmol/L before surgery to 8.36±0.62 mmol/L,and HbAlc decreased from 8.91±0.36%to 6.35±0.46% at the 12th week after surgery in GK operation rats. Meanwhile the serum INS increased from 32.76±2.37μIU/mL before surgery to 55.14±5.45 μIU/mL at the 12th week after surgery in the GK operation rats, with statistical significance(P＜0.05). Conclusion Gastric bypass surgery can significantly reduce fasting plasma glucose levels ,and improve glycometabolism in non-obese type 2 diabetes GK rats.关键词
2型糖尿病/胃旁路术/GK大鼠Key words
Type 2 diabetes mellitus/Gastric bypass/Goto-Kakizaki rats分类
医药卫生引用本文复制引用
曹超,周晓磊,尤胜义..胃旁路术对非肥胖型2型糖尿病大鼠糖代谢的影响[J].中国中西医结合外科杂志,2012,18(1):51-54,4.
