安徽农业科学2011，Vol.39Issue(36)：22319-22320,22497,3.
葛花滴丸的制备工艺及葛根素的含量测定
Research on Preparation Process of Dropping Pills from Pueraria lobata ( Willd.) Ohwi Bud and Content Determination of Puerarin
燕宪海 1张爱丽 1田友清1
作者信息
- 1. 江苏联合职业技术学院连云港中医药分院,江苏连云港222007
- 折叠
摘要
Abstract
[ Objective] To optimize the preparation process of dropping pills from Pueraria lobata (Willd. ) Ohwi bud and determine the content of puerarin. [Method] Taking the percent rate of roundness, weight difference and dissolve time as the indexes, the PEG6000-S-40 ratio, matrix-drug ratio, refrigerant temperature and dropping rate were optimized by orthogonal test with table L9 (3 ) in the course of preparing dropping pills from P. lobata (Willd. ) bud. And the content of puerarin in dropping pills was determined by HPLC. [Result] The optimal conditions for preparing dropping pills from P. lobata bud were as follows: 3:1 (g/g) , matrix-drug ratio 4:1 (g/g), refrigerant temperature 35-40 ℃ , 50 dropping pills per minute. And the average content of puerarin in 3 batches of dropping pills were (52, 26 ±1. 33) mg/g. [Conclusion] The preparation process of dropping pills from P. lobata bud is reasonable and repetitive. The dropping pills have good quality of appearance and meet the requirements of China Pharmacopoeia. And the HPLC method is advanced, accurate and reliable, which can be used to control the quality of dropping pills from P. lobata bud.关键词
葛花/滴丸/制备工艺/正交试验/葛根素/高效液相色谱Key words
P. Lobata bud/ Dripping pills/ Preparation process/ Orthogonal design/ Puerarin/ HPLC分类
医药卫生引用本文复制引用
燕宪海,张爱丽,田友清..葛花滴丸的制备工艺及葛根素的含量测定[J].安徽农业科学,2011,39(36):22319-22320,22497,3.
