安徽农业科学2012，Vol.40Issue(3)：1649-1651,3.
羧甲基甲壳素/海藻酸钠水凝胶溶胀性能及蛋白质控释性能研究
Swelling Property of Carboxymethyl Chitin/Sodium Alginate Hydrogel and Application in Protein Controlled Release Systems
摘要
Abstract
The carboxymethyl chitin and sodium alginate (SA) were mixed to prepare hydrogel. The effects of pH value, the proportion of SA to carboxymethyl chitin, the amount of SA and the dosage of crosslinker on the swelling behaviors of hydrogels have been studied. The results showed that the factors related above regulated their swelling behavior. The swelling ratio (SR) of hydrogel was the larger one at the condition in which the proportion of SA to carboxymethyl chitin, the concentration of SA, the concentration of carboxymethyl chitin and the dosage of crosslinker were 4:6, 4. 5% , 5.0% and 0. 30 separately. The release behavior of Bovine Serum Albumin (BSA) entrapped in the hydrogels was of distinctly difference with the changes of pH value of loading medium. The release ratio of BSA in CMCT hydrogel in the medium of pH = 1.2was5.6% while in the medium of pH =7.4, the total release ratio was 79. 8% . The hydrogel could protect macromolecular drugs in the sour environment of stomach, then, carried it into intestinal tract with high pH, finally, released, which showed the application potential in oral drugs controlled-release system.关键词
羧甲基甲壳素/海藻酸钠/水凝胶/溶胀率/控制释放Key words
Carboxymethyl chitin/ Sodium alginate/ Hydrogel/ Swelling ratio/ Controlled release分类
农业科技引用本文复制引用
高远,李蕊,郑翠芬,周珊,孙立苹..羧甲基甲壳素/海藻酸钠水凝胶溶胀性能及蛋白质控释性能研究[J].安徽农业科学,2012,40(3):1649-1651,3.基金项目
浙江省科技厅项目(2010c33070) （2010c33070）
浙江农林大学科技创新项目(100320). （100320）
