安徽农业科学2012，Vol.40Issue(4)：2044-2045,2.
小鼠实验性缺氧脑和肺组织MDA·LD含量和LDH活性变化
Changes of MDA and LD Content and LDH Activity in Brain and Lung of Mice with Eexperimental Hypoxia
刘芳 1杨翠军 2李志军 1刘开扬1
作者信息
- 1. 河北北方学院实验中心,河北张家口075000
- 2. 河北北方学院第一附属医院心胸外科,河北张家口075000
- 折叠
摘要
Abstract
[Objective] To determine the levels of malondialdehyde (MDA), lactic acid (ID) and activity of lactate dehydrogenase(LDH) in brain and lung of mice with experimental hypoxia. [ Method] 18 mice were randomly divided into three groups: normal control group (group 1) , acute hypoxia group (group 2) and acute CO poisoning group (group 3). The content of MDA,LD and activity of LDH in the mice.of three treatment groups were determined. [ Result] MDA and LD levels were significantly increased in the group 2 and group 3 compared to control group both in brain and lung. The activity of LDH of both group 2 and groups 3 was significantly lower in lung compared to control group, but showed no significant change in brain. MDA and LD contents in lung and brain were easy to change at the initial stage of hypoxia, their changes might be related to their damage degree. The change of LDH showed that lung was more sensitive than brain to the damage of free radicals produced by hypoxia. [ Conclusion ] The model provided theoretical support and practical guidelines for the hypoxia appeared in production of aquatic products and livestock farming systems.关键词
小鼠/缺氧/丙二醛/乳酸/乳酸脱氢酶Key words
Mice/ Hypoxia/ MDA/ LD/ LDH分类
农业科技引用本文复制引用
刘芳,杨翠军,李志军,刘开扬..小鼠实验性缺氧脑和肺组织MDA·LD含量和LDH活性变化[J].安徽农业科学,2012,40(4):2044-2045,2.
