摘要
Abstract
[Objective] To study the antibacterial activity of chemical constituents in C. Nanchuunensis. [ Method] The chemical constituents were firstly extracted by reflux method, , and then respectively extracted by petroleum ether, ethyl acetate and normal butanol, the extracts by ethyl acetate were analyzed by silica gel chromatography, and then gradient eluted by chloroform - methanol (10:0→0:10, V/V), the common compounds were detected by thin - layer rhromatography, antibacterial effects of compound 3, 4 and 5 were experimentally studied. [ Result ] Six compounds, including isoferulic acid, ferulic acid, 25-O-acetylcimigenol, cimidahuside C, 12β-hydroxycimigenol and β-sitosterol, were isolated from the dry rhizomes of Cimirifuga nnnchuanensis Hsiao. , and their structures were elucidated on the basis of spectroscopic analysis (IR, MS and NMR). Three of them were cycloartane triterpenoids. [Conclusion] Compounds 1-6 were extracted from C. Nanchuunensis for the first time, among them compound 3, 4 and 5 showed good antibacterial activities.关键词
南川升麻(Cimicifuga nanchuanensis Hsiao)/干燥根茎/化学成分/抗菌活性Key words
Cimicifuga nanchuanensis/ Dry rhizomes/ Chemical constituents/ Antimicrobial activity分类
医药卫生
