安徽医科大学学报2012，Vol.47Issue(1)：20-23,4.
高频超声评价阿霉素造模大鼠心功能的实验研究
Experimental study of high frequency echocardiography in evaluation of left ventricular function produced by adriamycin in rats
张书杰 1姜凡 1解翔 1张野 2吴运香 2张新书1
作者信息
- 1. 安徽医科大学第二附属医院超声诊断科,合肥,230601
- 2. 安徽医科大学第二附属医院麻醉科,合肥,230601
- 折叠
摘要
Abstract
To assess the effect of high frequency echocardiography on cardiac failure of rats produced by adriamycin ( ADM, doxorubicin ). Methods 30 SD rats were randomly divided into control group and ADM group. The model of cardiac failure of rats was made by injecting ADM into their tail veins. Then we observed two groups of rats with high frequency echocardiography. The myocardiac tissue of rats was observed by HE staining and VG staining method. Results High frequency echocardiography could reveal vividly the structure of rats' hearts. There was statistical significance between the normal control group and the ADM group in the changes of heart function which was concluded by high frequency echocardiography ( P < 0. 01 ). The results of HE staining and VG staining of rats' myocardiac tissue also proved that there was obviously injury. Conclusion High frequency echocardiography is an accurate and noinvasive method in assessing the changes of heart function of rats, and it is in according with phathology.关键词
超声心动图/心力衰竭/左心室功能/阿霉素Key words
echocardiography/ left ventricular function/ heart failure/ doxorubicin分类
医药卫生引用本文复制引用
张书杰,姜凡,解翔,张野,吴运香,张新书..高频超声评价阿霉素造模大鼠心功能的实验研究[J].安徽医科大学学报,2012,47(1):20-23,4.
