安徽医科大学学报2012，Vol.47Issue(1)：38-40,3.
多重耐药鲍曼不动杆菌外排泵机制的初步研究
Primary study on efflux pump mechanism in multidrug-resistant Acinetobacter baumannii
摘要
Abstract
To study the phenotype of the efflux pumps in multidrug- resistant Acinetobacter baumannii providing foundation for further study the mechanism of multidrug-resistant in Acinetobacter baumannii. Methods The minimum inhibitory concentrations ( MIC ) of five antibiotics, including imipenem, meropenem, ciprofloxacin gentamicin and ceftazidime with or without efflux pump inhibitor PA(3N were determined by agar dilution method. Results In addition of PAβN, MIC of 45 strains to imipenem, 70 strains to meropenem, 45 strains to ceftazidime, only 4 strains to ciprofloxacin decreased more than 4 folds, but no one strain to gentamicin. Conclusion Efflux pump mechanism is one of the causes of imipenem , meropenem and ceftazidime resistant in Acinetobacter baumannii , while which is not account for ciprofloxacin and gentamicin.关键词
鲍曼不动杆菌/多重耐药/外排泵/PAβNKey words
Acinetobacter baumannii/ multidrug resistance/ efflux pump/ PAβN分类
医药卫生引用本文复制引用
王友梅,沈继龙,沈继录,徐元宏..多重耐药鲍曼不动杆菌外排泵机制的初步研究[J].安徽医科大学学报,2012,47(1):38-40,3.基金项目
安徽省卫生厅科研课题(编号:09B095) （编号:09B095）
