安徽医科大学学报2012，Vol.47Issue(1)：71-74,4.
HE4、CA125、CA72-4、CA153、CA19-9、CYFRA21-1、TSH在妇科肿瘤诊断中的评价
The evaluation of HE4,CA125,CA72-4,CA153,CA19-9,CYFRA21-1,TSH in diagnosis of gynecological tumor
摘要
Abstract
To evaluate the value of human epididymis protein 4 ( HE4 ), cancer antigen 125 ( CA125 ), cancer antigen 724- ( CA72-4), cancer antigen 153 ( CA153 ), cancer antigen 19-9 ( CA19-9 ), CY-FRA21-1, thyroid-stimulating hormone ( TSH ) in clinical diagnosis of gynecologic tumor. Methods 114 cases of gynecological neoplasms and 40 cases of normal controls were gathered. Adopting enzyme linked immnosorbent assay ( ELISA ) to detect serum HE4 while electrochemiluminescence assay of Roche was employed to detect serum CA125, CA72^, CA153, CA19-9, CYFRA21-1 and TSH. Results Positive rates of HE4, CA125, CYFRA21-1 in patients with adenocarcinoma, HE4 in patient with squamous cell carcinoma, CA125 in patient with inflammatory reaction were significant higher than those in health control ( P <0. 05 ). Meanwhile, positive rates of CA125 in patients with adenocarcinoma were significant higher than those in patients with leiomyoma, other tumor and squamous cell carcinoma ( P <0. 05 ),and positive rates of both HE4 and CA125 in patient with malignant tumor were significant higher than those in benign disease patients and health control( P <0. 05 ). Moreover, positive rates of CYFRA21-1 in patients with malignancy were significant higher than those in benign disease patients and health control, and there was significant difference between patients with adenocarcinoma and inflammatory reaction ( P < 0. 05 ). Conclusion Both CA125 and CYFRA21-1 are useful in the diagnosis and differential diagnosis of gynecological tumor, and the combined detection is useful in the diagnosis of gynecological tumor.关键词
人附睾蛋白4/鳞癌/腺癌/平滑肌瘤/炎症反应/妇科肿瘤Key words
human epididymis protein 4/ squamous cell carcinoma/ adenocarcinoma/ leiomyoma/ inflammatory reaction/ gynecological tumor分类
医药卫生引用本文复制引用
罗兵,董秋萍,李涛,徐元宏,熊自忠,肖春红..HE4、CA125、CA72-4、CA153、CA19-9、CYFRA21-1、TSH在妇科肿瘤诊断中的评价[J].安徽医科大学学报,2012,47(1):71-74,4.基金项目
国家自然基金(编号:30801088) （编号:30801088）
安徽省卫生厅临床医学应用技术项目(编号:2008A022) （编号:2008A022）
安徽省高校自然科研基金(编号:KJ2009B078) （编号:KJ2009B078）
