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胃肠道间质瘤临床病理及免疫组化表达的分析

赵文娣祁义军王岳君吴继锋

安徽医科大学学报2012，Vol.47Issue(4)：454-457,4.

胃肠道间质瘤临床病理及免疫组化表达的分析

Clinicalpathological and immunohistochemical study of gastrointesitinal stromal tumors

赵文娣 ¹祁义军 ²王岳君 ¹吴继锋¹

作者信息

1. 安徽医科大学病理学教研室,合肥,230032
2. 安徽医科大学第一附属医院普外科,合肥,230022
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摘要

Abstract

To investigate the clinicalpathological and immunohistochemical features of gastrointestinal stromal tumors( GIST ). Methods The medical records of 181 patients underwent surgical resection for GIST were reviewed. Immunohistochemical staining of CD117, D0G1, CD34, SMA, Desmin, S100 was performed in 181 cases of GIST. Results The major morphology of GIST was spindle-shaped. The positive rates of CD117, D0G1, CD34, SMA, Desmin, S100 were 91. 2% , 89. 5% , 77. 9% , 35. 6% , 6. 1% , 11. 0% respectively. There were 83. 4%( 151/181 )tumors positive for both CD117 and DOG1. 68. 8%( 11/16 )tumors positive for DOGlwhile negative for CD1117. The immunohistochemical expression of DOG1 was significantly related with age, tumor size and risk classification( P <0. 05 ). Conclusions Spindle-shaped is the major morphology of GIST. CD117 and DOG1 are sensitive and effective markers for GIST. Combined detection of CD117, DOG1 and CD34 may improve the diagnosis of GIST. SMA, Desmin and S100 play an important role in the differential diagnosis of GIST. Negtive expression of DOG1 may suggest an poor prognosis.

关键词

胃肠道间质瘤/DOG1/CD117

Key words

gastrointestinal stromal tumors /DOG1 /CD117

分类

医药卫生

引用本文复制引用

赵文娣,祁义军,王岳君,吴继锋..胃肠道间质瘤临床病理及免疫组化表达的分析[J].安徽医科大学学报,2012,47(4):454-457,4.

安徽医科大学学报

OA北大核心CSTPCD

ISSN：1000-1492

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