巢湖学院学报Issue(6)：104-107,4.
氯化锌催化三取代基咪唑的合成
ZINC CHLORIDE CATALYZED SYNTHESIS OF 2,4,5-TRISUBSTITUTED IMIDAZOLES
摘要
Abstract
Direct one-pot synthesis of various 2,4,5-trisubstituted imidazoles from benzil, aldehydes and ammonium acetate us- ing zinc chloride as the catalyst in EtOH is described with good product yields. The influences of reaction conditions such as ratio of zinc chloride, temperature were described. The yield of 2,4,5-triphenylimidazole is 86% under the optimized reaction conditions were that 78℃, n（benzil）：n（benzaldehyde）：n（NI-14OAe）：n（ZnC12）=1.0：1.0：2.5： 0.2, and 3h. This method is relatively simple and mild. Such method will contribute to the sysnthesis of 2,4,5-trisubstituted imidazoles to some extent. In this paper, a possible reaction mechanism is proposed.关键词
氯化锌/三取代基咪唑/苯偶酰Key words
zinc chloride/2,4,5-trisubstituted imidazoles/benzyl分类
化学化工引用本文复制引用
任一鸣,张旭,杨仁春..氯化锌催化三取代基咪唑的合成[J].巢湖学院学报,2011,(6):104-107,4.基金项目
安徽工程大学引进人才科研启动基金 （）
