重庆大学学报：自然科学版2011，Vol.34Issue(11)：100-104,5.
庆大霉素/水杨酸/壳聚糖复方纳米粒的制备及体外释放
Preparation of the gentamicin and salicylic acid-loaded chitosan nanoparticles and its in vitro releasing investigation
摘要
Abstract
Gentamycin（GM） and salicylic acid（SA） loaded chitosan（CS） nanoparticles are prepared and used to inhibit the ototoxicity of GM.Nanoparticles are prepared via the cross-linking method by CS and sodium tripolyphosphate.The characteristics of nanoparticles such as size,zeta potential,shape,loading capacity,and in vitro release profiles are determined.The nanoparticles are spherical in shape with an average diameter of 40 nm.The entrapment efficient of GM and SA is（91.24±0.24）% and（80.75±0.15）% respectively,and loading capacity are（34.15±1.02）% and（38.35±0.48）%.The drug release shows good sustained-release effect and follows ambiexponent kinetic equation.It demonstrates that GM and SA loaded CS nanoparticles have promising potential effect on antagonism ototoxicity of GM,and the nephrotoxicity may be also decreased through the expected sustained-release characteristics of CS nanoparticles.关键词
庆大霉素/耳毒性/水杨酸/壳聚糖/纳米粒Key words
gentamicin/ototoxicity/salicylic acid/chitosan/nanoparticles分类
医药卫生引用本文复制引用
季金苟,郝石磊,刘玮琦,吴丹君,徐溢,陈际达..庆大霉素/水杨酸/壳聚糖复方纳米粒的制备及体外释放[J].重庆大学学报：自然科学版,2011,34(11):100-104,5.基金项目
重庆市自然科学基金资助项目 （）
重庆大学研究生科技创新基金资助项目 （）
重庆大学211工程三期创新人才培养计划建设项目 （）
