重庆医学2012，Vol.41Issue(4)：333-335,338,4.DOI:10.3969/j.issn.1671-8348.2012.04.008
不同GnRH-a降调节方案用于子宫内膜异位症合并不育者的体外受精-胚胎移植研究
Study on outcome of IVF-ET conducted with different GnRH-a down-regulation protocols on infertility patients with endometriosis
邓华丽 1叶虹 1裴莉 1曾品鸿 1黄国宁1
作者信息
- 1. 重庆市妇幼保健院遗传与生殖研究所,400013
- 折叠
摘要
Abstract
Objective To compare the outcome of in vitro fertilization-embryo transfer ( IVF-ET) conducted with different down-regulation protocols on infertile patients with endometriosis. Methods A retrospective analysis was conducted on infertile patients with endometriosis regarding the IVF-ET outcomes in our center from January 2008 to December 2010. The study group included 74 patients applied with prolonged protocol (group A). The control group included 177 patients applied with long protocol in the same time. Results The proportion of severe endometriosis patients in the group A was bigger than that in the group B. Both the initial and the total dose of Gn of the study group were higher than that of the control group. The group A had smaller follicle number,oocyte number and MII oocyte number (P<0. 05). There was no obvious difference in the fertilization rate,cleavage rate, cycle cancel rate, transferable embryo number, high quality embryo number, transferred embryo number, abortion rate and ectopic pregnancy rate between the two group s (P>0. 05). The transferable embryo rate and high quality embryo rate in the group A were obviously higher than those of the group B(P<0. 05). The clinical pregnancy rate and implantation rate in the group A were higher slightly than those of the group B,but there was no statistically significant difference (P>0.05). Conclusion There is improvement of embryo quality and increasing tendency in clinical pregnancy rate and implantation rate using the prolonged protocol than u-sing the long protocol when IVF-ET is conducted on infertility patients with endometriosis.关键词
子宫内膜异位症/体外受精-胚胎移植/GnRH-a降调节/控制性促排卵/长方案/超长方案Key words
endometriosis/infertility/in vitro fertilization-embryo transfer/GnRH-a down-regulation/controlled ovarian stimula-引用本文复制引用
邓华丽,叶虹,裴莉,曾品鸿,黄国宁..不同GnRH-a降调节方案用于子宫内膜异位症合并不育者的体外受精-胚胎移植研究[J].重庆医学,2012,41(4):333-335,338,4.
