重庆医学2012，Vol.41Issue(4)：344-346,3.DOI:10.3969/j.issn.1671-8348.2012.04.012
胰岛素强化治疗对重型颅脑损伤影响的Meta分析
A Meta analysis of intensive insulin therapy in severe traumatic brain injury
章向成 1张红 2尚福泰 1喻荣彬3
作者信息
- 1. 南京医科大学附属淮安第一医院ICU,江苏淮安,223300
- 2. 南京医科大学附属淮安第一医院内分泌科,江苏淮安,223300
- 3. 南京医科大学公共卫生学院流行病与统计学系,210029
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of intensive insulin therapy(IIT) in the treatment of severe traumatic brain injury(TBI). Methods According to the creteria of systematic review, the data from randomized controlled trials regarding the association between IIT and TBI were derived through electronic search of PubMed and Chinese. A meta analysis was performed on mrobility and infection rate of the two groups. And publication bias was assessed. Results Total 1341 cases involved in 13 papers met the inclusion criteria. The test for heterogeneity showed that no heterogeneity existed among the included papers, which allowed to use fixed effect model analysis. The result of funnel plots and fail-safe number showed lower in publication bias. The incorporation analysis suggested that IIT group had lower mortality(P<0. 01) and lower infection rate(P<0. 01). Conclusion The clinical evidences available so far indicate that IIT is benencial to severe TBI.关键词
颅脑损伤/胰岛素强化治疗/Meta分析Key words
craniocerebral trauma/intensive insulin/Meta analysis引用本文复制引用
章向成,张红,尚福泰,喻荣彬..胰岛素强化治疗对重型颅脑损伤影响的Meta分析[J].重庆医学,2012,41(4):344-346,3.
