重庆医学2012，Vol.41Issue(4)：349-351,3.DOI:10.3969/j.issn.1671-8348.2012.04.014
吡格列酮对糖尿病大鼠氧化应激和肾组织基质积聚的影响
Effect of pioglitazone on oxidative stress and accumulation of matrix in diabetic rats
张红 1胡长军 1陆卫平1
作者信息
- 1. 南京医科大学附属淮安第一医院内分泌科,江苏淮安,223300
- 折叠
摘要
Abstract
Objective To investigate the effect of pioglitazone on oxidative stress and accumulation of matrix in diabetic rats. Methods All rats were randomized into 3 groups: normal control rats (group NO, diabetic rats (group DM) , diabetic rats treated with pioglitazone(group DP). After 8 weeks of treatment,the kidney index,microalbuminuria,malondialdehyde,catalase,Cu,Zn su-peroxide dismutase in nephridial tissue were measured by chromatometry,the pathologic change of kidney was measured. Furthermore, collagen-Ⅳ expression in kidneny was observed by immunohistochemistry. Results The kidney index, microalbuminuria, MDA and the expression Col-Ⅳ in group DM were higher significantly than those in the group NC and group DP(P<0. 01) , Mor-ever,CAT in the group DM was significantly lower than that in the other two groups(P<0. 01). Conclusion Pioglitazone improves diabetic nephropathy through downregulating the expression of TGF-β1 and upregulating MMP-9 in diabetic rats.关键词
糖尿病肾病/氧化应激/Ⅳ型胶原/吡格列酮Key words
diabetic nephropathies/oxidative stress/type Ⅳ collagen/pioglitazone引用本文复制引用
张红,胡长军,陆卫平..吡格列酮对糖尿病大鼠氧化应激和肾组织基质积聚的影响[J].重庆医学,2012,41(4):349-351,3.
