重庆医学2012，Vol.41Issue(5)：442-444,448,4.DOI:10.3969/j.issn.1671-8348.2012.05.010
255例初治鼻咽癌调强适形放疗临床观察
Clinical observation of IMRT in 255 of primitive nasopharyngeal carcinoma
肖帅 1王仁生 1黄素宁 1戴刚毅 1马姗姗1
作者信息
- 1. 广西医科大学第一附属医院放疗科,南宁,530003
- 折叠
摘要
Abstract
Objective To analyse the clinical efficacy of intensity modulated radiation therapy(IMRT) for primitive nasopharyn-geal carcinoma(NPC). Methods 255 of primitive NPC received IMRT. The target volumes were divided into the gross tumor volume of nasopharynx (GTVnx),the gross tumor volume of positive cervical lymph node (GTVnd), the first clinical target volume (CTV1) ,and the second clinical target volume(CTV2). The average doses were 78. 4Gy,65. 8Gy,67. 7Gy and 61. 4Gy respectively. Among them, 172 cases received induction chemotherapy plus concurrent chemoradiotherapy. The survival differences were compared by Kaplan-Merier method, Log-rank test and Cox multivariate regression analysis. Results The median follow-up interval was 19 months. The 1-year,2-year and 3-year overall survival rate were 100% ,96. 1% and 95. 7% , the local-regional control rates were 96. 8%,94. 5% and 94. 5% ,the distant metastasis-free survival rate were 91. 4%, 87. 8% and 85. 5% respectively. The univa-riate analysis showed that the four prognostic factors included age,clinical stage,T stage, N stage had statistical significance to the influence on survival,but the pathological classification had no statistical significance to the influence on survival. The multivariate analysis only identified two prognostic factors: age and N stage. Conclusion For primitive NPC,IMRT could lead to ideal dose distributions, the surrounding normal tissue are well protected with acceptable toxic and side effects. The clinical results are satisfactory.关键词
鼻咽肿瘤/调强适形放疗/预后Key words
nasopharyngeal neoplasms/intensity modulated radiation therapy/prognosis引用本文复制引用
肖帅,王仁生,黄素宁,戴刚毅,马姗姗..255例初治鼻咽癌调强适形放疗临床观察[J].重庆医学,2012,41(5):442-444,448,4.
