重庆医学2012，Vol.41Issue(5)：455-457,封3,4.DOI:10.3969/j.issn.1671-8348.2012.05.015
人颅咽管瘤裸鼠皮下移植瘤模型的初步建立
Establishment of subcutaneous xenotransplanted tumor model of human craniopharyngioma in nude mice
摘要
Abstract
Objective To establish a preliminary subcutaneous xenotransplanted tumor model of human craniopharyngioma in nude mice. Methods Craniopharyngioma cells were primaryly cultured by trypsin digestion. Then, the purified cells in third passage were implanted subcutaneously into the nude mice. The specimens were investigated by microscope. Results Craniopharyngioma cells could survive in the nude mice. The xenograft could be found on 8 d after implanting. The tumor formation rate was 33. 3%. The disorder growth of the squamous epithelial tumor cells could be subcutaneously found with microscope in nude mice. Conclusion The subcutaneously xenotransplanted tumor model of human craniopharyngioma in nude mice is successfully established by the craniopharyngioma cells,which may benefit to further studies on this tumor.关键词
颅咽管瘤/裸鼠/移植瘤模型Key words
craniopharyngioma/nude mice/xenotransplanted tumor model引用本文复制引用
周杰,漆松涛,潘军,颜小荣,张超..人颅咽管瘤裸鼠皮下移植瘤模型的初步建立[J].重庆医学,2012,41(5):455-457,封3,4.基金项目
国家自然科学基金资助项目(81072067) （81072067）
广东省自然科学基金资助项目(S2011010003063). （S2011010003063）
