重庆医学2012，Vol.41Issue(5)：461-462,465,3.DOI:10.3969/j.issn.1671-8348.2012.05.017
葡萄糖酸锌对心肌缺血/再灌注损伤保护作用的动物实验研究
Animal experiment on cardioprotective effects of zinc gluconate on myocardial ischemia/reperfusion injury
摘要
Abstract
To investigate the protective effect of zinc gluconate on myocardial ischemia/reperfusion injury in rats and its possible mechanism. Methods Fifty SD rats were randomly divided into five groups: sham, model, ZG of low, middle and high dose groups. Left coronary artery braid,silk suture tense and silk suture slacken were adopted to establish the model of myocardial ischemia/reperfusion injury in anesthetized rats. At 1 h after the last administration,the rats of ZG three groups were ligated for 30 min and reperfused for 60 min in the left anterior descending branch of coronary artery. Myocardial tissue was collected at the end of reperfusion for detecting the activitise of Na+-K+-ATPase and SOD, the contents of IL-lβ,Ca2+ and MDA. Results Compared with the model group, the three different dose groups of ZG increased the activitise of Na+-K + -ATPase and SOD, decreased the contents of IL-lβ,Ca and MDA. Conclusion ZG has protective effects on myocardial ischemia/reperfusion injury. The mechanism is the inhibition of hydroxyl radical ( ·OH) generation, the reduction of lipid peroxidation,the improvement of cardiac energy metabolism, the reduction of calcium overload and the inhibition of inflammatory response.关键词
再灌注损伤/葡萄糖酸锌/钠-钾-ATP酶/白细胞介素1βKey words
reperfusion injury/zinc gluconate/Na+-K + -ATPase/interleukin-lβ引用本文复制引用
刘丹,孙品兰,罗明军,黄春,张乐星,谭祥惠..葡萄糖酸锌对心肌缺血/再灌注损伤保护作用的动物实验研究[J].重庆医学,2012,41(5):461-462,465,3.基金项目
重庆市教委科学技术研究项目(KJ092101). （KJ092101）
