重庆医学2012，Vol.41Issue(6)：552-553,556,3.DOI:10.3969/j.issn.1671-8348.2012.06.013
生长抑素与泮托拉唑钠治疗重症急性胰腺炎的疗效及对血清炎性因子的影响
Clinical efficacy of somatostatin and pantoprazole sodium for treating severe acute pancrcatitis and their effects on inflammatory cytokines
丁洪涛 1吴玉芳2
作者信息
- 1. 华中科技大学同济医学院附属武汉市中西医结合医院急诊科,武汉,430022
- 2. 华中科技大学同济医学院附属武汉市中西医结合医院消化内科,武汉,430022
- 折叠
摘要
Abstract
Objective To study the clinical efficacy of somatostatin and pantoprazole sodium for treating sever acute pancreatitis (SAP) and their effects on inflammatory cytokines. Methods 74 cases of SAP were randomly divided into the control group and the treatment group, 37 cases in each group. Besides routine treatment, the control group recerived pantoprazole sodium and the treatment group was given the combination therapy of somastatin and pantoprazole sodium with the treatment duration of 7 d. The clinical indexes including the alleviation time of abdominal pain,intestinal function recovery time and ventilator withdrawal time,and serum inflammatory cytokines including interleukins-8(IL-8) ,high-sensitivity C-reactive protein(Hs-CRP) and tumor necrosis fac-tor-α(TNF-α) were compared between the two groups. Results The alleviation time of abdominal pain,intestinal function recovery time and ventilator withdrawal time in the treatment group were better than those in the control group (P<0.01). The levels of serum IL-8,Hs-CRP and TNF-αin the treatment group were lower than those in control group (P<0.01). Conclusion Combination of somatostatin and pantoprazole sodium can significantly decrease serum inflammatory cytokine, and increase clinical efficacy in patients with SAP.关键词
胰腺炎/生长抑素/泮托拉唑钠/白细胞介素8/高敏C反应蛋白/肿瘤坏死因子αKey words
pancreatitis/ somatostatin/ pantoprazole sodium/ interleukins-8/ high-sensitivity C-reactive protein/ tumor necrosis factor-α引用本文复制引用
丁洪涛,吴玉芳..生长抑素与泮托拉唑钠治疗重症急性胰腺炎的疗效及对血清炎性因子的影响[J].重庆医学,2012,41(6):552-553,556,3.
