重庆医学2012，Vol.41Issue(6)：573-574,577,3.DOI:10.3969/j.issn.1671-8348.2012.06.022
宫颈细胞学检查为意义不明确的非典型鳞状细胞患者的分流处理探讨
Exploring in management of women with atypical squamous cells of undetermined significance
张宏珍 1张巧玉 1成争先 1温娜 1陈小燕1
作者信息
- 1. 中国人民解放军第三○九医院妇产科,北京,100091
- 折叠
摘要
Abstract
Objective To find the sensitivity,specificity,and positive and negative predictive values of the high risk group human papillomavirus (HPV) DNA testing as a triage tool to detect in women with a cytologic smear showing atypical squamous cells of undetermined significance (ASCUS). Methods All new cases with cytologic smears showing ASCUS presented in our hospital from July 2008 to November 2010, excluding known cases of HSILs and pregnancies, were enrolled. Cervical cell samplings were done by cervical cytobrush technique and tested for high risk group HPV with the hybrid capture 2 (HC2) test. All participants were examined under a colposcope. Then cervicographs were taken before colposcopic directed cervical biopsies were done. Results Among patients investigated, 114 patients were diagnosed with cervical intraepithelial neoplasia(CIN, 52.29 % ). Comparing the col poscopic result with biopsied result,the coincidence rate was 59.65% in high grade CIN and squamous cell carcinoma(SCC). The prevalence of CIN in the high risk HPV group was 85.84% and was obviously higher than that of HPV negative group(P<0.05).31 of 33 patients with high grade CIN were HPV positive,2 patients were HPV negative,2 cases were high risk HPV positive.Conclusion High risk group HPV detection can be used as an additional triage test to detect HSILs in women having ASCUS with high sensitivity and negative predictive value.关键词
宫颈上皮内瘤样病变/意义不明确的非典型鳞状细胞/人乳头状瘤病毒Key words
cervical intraepithelial neoplasia/ atypical squamous cells of undetermined significance/ human papillomavirus引用本文复制引用
张宏珍,张巧玉,成争先,温娜,陈小燕..宫颈细胞学检查为意义不明确的非典型鳞状细胞患者的分流处理探讨[J].重庆医学,2012,41(6):573-574,577,3.
