重庆医学2012，Vol.41Issue(8)：729-731,3.DOI:10.3969/j.issn.1671-8348.2012.08.001
基于Hyper-CVAD/MA方案的强化化疗后自体外周血干细胞移植治疗淋巴瘤的研究
A study of malignant lymphoma treatment using Hyper-CVAD/MA regimen-based intensive chemotherapy followed by autologous peripheral blood stem cell transplantation
王劲 1周旭 1刘瑜 1彭翠翠1
作者信息
- 1. 第三军医大学大坪医院野战外科研究所血液科,重庆,400042
- 折叠
摘要
Abstract
Objective To discuss Hyper CVAD/MA regimen based high dose intensive chemotherapy followed by autologous peripheral blood stem cell transplantation(APBSCT) for malignant lymphoma treatment and its therapeutic effect. Methods 23 pa tients with malignant lymphoma were subjected to conventional CHOP chemotherapy. After every 2 3 courses of the conventional chemotherapy, Hyper CVAD/MA regimen was employed for intension and rituximab was administrated. Preparative regimen inclu ding NEAC (12 cases) ,NEAM (8 cases) and NEAM+TBI (3 cases) was conducted before APBSCT. 5 patients with diffuse large B cell type lymphoma, 1 patient with mantle cell type lymphoma and 1 patient with follicular cell type ( Ⅲ b stage) lymphoma were treated with rituximab in addition before APBSCT. Results All patients received successful hematopoietic reconstitution. After transplantation,the duration of their peripheral blood absolute neutrophil count (ANC) achieving ≥0.5 × 109/L and the platelet (PLT) achieving≥20×109/L were (12. 8 ± 2. 5) d and (16. 1 ± 4. 1) d,respectively. The follow up of 45 -1 092 days showed 15 disease free survival,5 recurrence and 3 dead. The overall survival rate and disease free survival rate of patients were 86. 96%(20/ 23) and 65. 22% (15/23), respectively. Conclusion Hyper CVAD/MA regimen based high dose intensive chemotherapy followed by APBSCT for malignant lymphoma treatment is safe and may improve the disease free survival rate of patients.关键词
抗肿瘤联合化疗方案/外周血干细胞移植/移植/自体/淋巴瘤Key words
antineoplastic combined chemotherapy protocols/ peripheral blood stem cell transplantation/ transplantation,autolo gous/ lymphoma引用本文复制引用
王劲,周旭,刘瑜,彭翠翠..基于Hyper-CVAD/MA方案的强化化疗后自体外周血干细胞移植治疗淋巴瘤的研究[J].重庆医学,2012,41(8):729-731,3.
