重庆医学2012，Vol.41Issue(8)：748-750,3.DOI:10.3969/j.issn.1671-8348.2012.08.008
RhD阴性孕妇妊娠RhD阳性胎儿与新生儿溶血病的相关性分析
Correlation analysis of hemolytic disease of newborn and RhD negative pregnant women carrying RhD positive fetus
摘要
Abstract
Objective To explore the correlation of prenatal detection rate of immune anti-D antibody of pregnant women with RhD negative blood type and the incidence rate of postpartum hemolytic disease of newborn(HDN). Methods 137 prenatal blood samples of pregnant women with RhD negative blood type and 40 postpartum blood samples were collected from January 2007 to December 2010. Their prenatal detection rate of anti-D antibody, incidence rate of postpartum HDN and their relationship with maternal-fetal ABO-blood group compatibility were analyzed. Results Anti-D antibody was detected in 16(12. 60%) pregnant women with RhD negative blood type and history of several pregnancies, and was not detected in 10 women in their first pregnancy. The prenatal detection rate of serum anti-D antibody was lower than that after delivery(P<0.05). The incidence rate of HDN for RhD negative pregnant women carrying RhD positive fetus with maternal-fetal ABO-blood group incompatibility was higher than those with maternal-fetal ABO-blood group compatibility(P<0.05) ,and the incidence rate of HDN for those belong to ABO-blood group system was higher than those belong to Rh-blood group system(P<0.05). No correlation was found between the detection rate of anti-D antibody and the maternal-fetal ABO-blood group compatibility(P>0. 05). Conclusion The correlation of prenatal detection rate of anti-D antibody of RhD negative pregnant women and the incidence rate of postpartum HDN is not clear. ABO-blood group incompatibility has a protective effect on RhD negative pregnant women from RhD-HDN, but no effect on detection rate of anti-D antibodies.关键词
抗D抗体/Rh血型系统/ABO血型系统/新生儿溶血病Key words
anti-D antibodies/Rh blood-group system/ ABO blood-group system/ hemolytic disease of newborn引用本文复制引用
何子毅,刘赴平,胡应明,张建强..RhD阴性孕妇妊娠RhD阳性胎儿与新生儿溶血病的相关性分析[J].重庆医学,2012,41(8):748-750,3.基金项目
东莞市科技局科技计划资助项目(2009-145). （2009-145）
