重庆医学2012，Vol.41Issue(9)：859-860,863,3.DOI:10.3969/j.issn.1671-8348.2012.09.010
TACE治疗化疗后进展期结直肠癌肝转移的临床研究
Clinical research of TACE treatment of advanced colorectal carcinoma with hepatic metastases after chemotherapy
全毅 1何柱光 1李祥厦1
作者信息
- 1. 广东省肇庆市第一人民医院肿瘤科,526000
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of transcatheter arterial chemoembolization(TACE) in the treatment of advanced colorectal carcinoma with hepatic metastases after chemotherapy. Methods 45 patients with advanced colorectal carcinoma and hepatic metastases who had received FOLFOX6 chemotherapy previously and had been assessed as tumor progression were enrolled. Fluorouracil,oxaliplatin and lipiodol were infused via hepatic artery to perform chemoembolization, and the recent efficacy, adverse reactions and 1-year survival rate were observed. Peripheral blood of patients were collected before and one week after TACK. Flow cytometry was applied to detect the T-lymphocyte subgroups in peripheral blood. Results Alanine aminotransferase (ALT) and CD4+ in peripheral blood of patients one week after TACE were higher than those before TACE(P<0. 05) , while the differences of CD3+ ,CD4+/CD8+ showed no statistical significance(P>0. 05). The common adverse reaction after TACE were mainly abdominal pain,nausea,vomiting,fever and liver function damage. There were 0 case of complete remission, 14 cases of partial remission and 21 cases of stability in 45 patients. Conclusion TACE can be served as effective second-line remedial regimen in treatment of patients with colorectal carcinoma and hepatic metastases who failed first-line chemotherapy.关键词
化学栓塞,治疗性/结直肠肿瘤/肿瘤转移Key words
chemoembolization,therapeutic/colorectal neoplasms/neoplasm metastasis引用本文复制引用
全毅,何柱光,李祥厦..TACE治疗化疗后进展期结直肠癌肝转移的临床研究[J].重庆医学,2012,41(9):859-860,863,3.
