中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(3)：146-148,3.DOI:10.1007/s10330-011-0931-3
人类胰腺癌组织中多环芳烃含量的测定及意义
The detection and significance of polycyclic aromatic hydrocarbons in human pancreatic cancer
摘要
Abstract
Objective: The aim of this study was to investigate the effect of polycyclic aromatic hydrocarbons (PAHs) on the occurrence of human pancreatic cancer.Methods: PAHs in human pancreatic cancer, adjacent pancreatic cancer tissues and tissues without pancreatic cancer were extracted by ultrasonic extraction (UE).And then the extracts were cleaned up by solid phase extraction and analyzed by high performance liquid chromatography (HPLC) with fluorescence spectroscopy.Results: Four kinds of PAHs were detected, which were chrysene, 2-methylanthracene, pyrene and benzo (a) pyrene.The contents of the four PAHs were not statistically significant between pancreatic cancer and adjacent tissues (P > 0.05).The contents of 2-methylanthracene, pyrene and benzo (a) pyrene in pancreatic cancer and adjacent tissues were higher than tissues without pancreatic cancer, the differences were statistically significant (P < 0.05).The contents of chrysene in the three kinds of pancreatic tissues were not statistically significant (P > 0.05).Conclusion: PAHs were found in human pancreatic tissues.Human pancreatic tissues have extremely strong ability of bio-concentrating PAHs.PAHs might play an important role in the occurrence of human pancreatic cancer.关键词
pancreatic neoplasms/ polycyclic aromatic hydrocarbons (PAHS)/ high performance liquid chromatography (HPLC)Key words
pancreatic neoplasms/ polycyclic aromatic hydrocarbons (PAHS)/ high performance liquid chromatography (HPLC)引用本文复制引用
Shuntao Liu,Limin Lun..人类胰腺癌组织中多环芳烃含量的测定及意义[J].中德临床肿瘤学杂志（英文版）,2012,11(3):146-148,3.基金项目
Supported by a grant from Key Laboratory of Marine Spill Oil Identification and Damage Assessment Technology (No.200902). （No.200902）
