电化学2011，Vol.17Issue(4)：433-437,5.
β-环糊精与阿霉素表面包络作用的电化学研究
Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin
摘要
Abstract
The β-cyclodextrin（β-CD） modified gold electrode（β-CD/Au） was fabricated to study the electrochemical behavior of adriamycin（ADM）.The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface.At 25 ℃,the complexing constant（k） was 9.54×104 L·mol-1 in pH=7.0.The k values changed regularly with temperature,and the most suitable temperature of the surface inclusion reaction was 30 ℃.The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1.The cathodic peak current（Ip） of ADM was proportional to the concentration of ADM in the 20~40 μmol·L^-1.The linear regression equation for the quantitative determination of ADM concentration（C） by β-CD/Au was Ip=2.024＋0.0057C with a correlation coefficient of 0.9911.The detection limit was 6.5 μmol·L-1.关键词
阿霉素/β-环糊精/修饰电极/包络Key words
adriamycin/β-cyclodextrin/modified electrode/complex分类
医药卫生引用本文复制引用
石健,张其平,王南平..β-环糊精与阿霉素表面包络作用的电化学研究[J].电化学,2011,17(4):433-437,5.基金项目
江苏省自然科学基金重点项目（BK2010034）资助 （）
