南方医科大学学报2011，Vol.31Issue(12)：1963-1967,5.DOI:44-1627/R.20111210.2100.001
严重早产儿视网膜病变相关因素分析
Risk factors for severe retinopathy of prematurity in premature infants: a single-center study
摘要
Abstract
Objective To evaluate the incidence and risk factors for severe retinopathy of prematurity (ROP) in preterm infants.Methods Between May,2008 and May,2011,a total of 957 preterm infants at 4-6 weeks of chronological age or 32 weeks of postmenstrual age underwent retinal evaluation by RetCamⅡ in our center,and the data of infants with ROP in any stage were analyzed.Results Among the 957 preterm infants,we found 86 (8.99%) infants to have ROP in different stages,including 60(6.27%) with mild ROP and 26 (2.72%) with severe ROP.The birth weight and gestational age of the infants with severe ROP averaged 1 420.40+328.64 g and 29.88+1.67 weeks,as compared to 1 593.28±339.30 g and 31.78±2.53 weeks in those with mild ROP,respectively,showing a significant difference between the two groups (P＜0.005).The significant variables for severe ROP included gestational age (P=0.001),birth weight (P=0.035),1 min Apgar score (P=0.001),5 min Apgar score (P=0.005),number of blood transfusions (P=0.032),and the presence of apnea (P=0.04) and retinal hemorrhage (P=0.000).Gestational age and retinal hemorrhage were the independent risk factors for severe ROP (OR=0.353,95%CI 0.163-0.763,P=0.008; OR=26.133,95%CI 3.042-224.501,P=0.035).Conclusion Severe (R)OP tends to have a decreasing incidence and occurs more often in more mature preterm infants.The affected infants have the characteristics of the first epidemics.Gestational age and retinal hemorrhage are independent predictive factors for severe ROP.关键词
早产儿视网膜病变/发病率/相关因素Key words
retinopathy/ prematurity/ incidence/ risk factors分类
医药卫生引用本文复制引用
柯晓云,莒瑞红,张家庆,陈慧,魄二霞,陈晓虹..严重早产儿视网膜病变相关因素分析[J].南方医科大学学报,2011,31(12):1963-1967,5.基金项目
Supported by Natural Science Foundation of Guangdong Province (7005196).广东省自然科学基金(7005196) （7005196）
