南方医科大学学报2011，Vol.31Issue(12)：1968-1973,6.DOI:44-1627/R.20111207.1017.002
钆贝葡胺和钆喷酸葡胺在磁共振增强扫描诊断单发脑转移瘤中照研究
Efficacy of gadobenate dimeglumine vs gadopentetate dimeglumine in contrastenhanced magnetic resonance imaging for diagnosis of solitary brain metastases
摘要
Abstract
Objective To compare gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) for their efficacy as contrast agents in contrast-enhanced magnetic resonance imaging (MRI) for diagnosis of solitary brain metastases (SBM). Methods We conducted an intra-individual study of contrast-enhanced T1-weighted MRI (TiWI) data from 27 Chinese patients with suspected SBM to compare the enhancement findings of two different MRI contrast agents, Gd-BOPTA and Gd-DTPA (at equivalent doses of 0.1 mmol/kg), for the detection of SBM. All the patients underwent two identical MRI examinations on a 3.0-T MRI scanner first with Gd-DTPA and then with Gd-BOPTA. Evaluation of the contrast enhancement was performed qualitatively (border delineation, extent, internal morphology, and contrast enhancement) and quantitatively (lesion-to-brain ratio, contrast-to-noise ratio, and percent enhancement) by 3 independent, fully blinded, and highly experienced neuroradiologists. Results Qualitative assessment by readers revealed a significant overall preference (P0.05) for Gd-BOPTA over Gd-DOTA in terms of lesion border delineation, extent, lesion internal morphology, and contrast enhancement. Quantitative assessment also revealed a significant better performance of Gd-BOPTA in light of lesion-to-brain ratio (P<0.05), contrast-to-noise ratio (P<0.05), and percent enhancement (P<0.05). Conclusion At an equivalent dose, Gd-BOPTA allows better contrast enhancement of SBM than Gd-DTPA in MRI.关键词
钆贝葡胺/莫迪司/钆喷酸葡胺/脑转移瘤/磁共振成像Key words
gadobenate dimeglumine/ MultiHance/ gadopentetate dimeglumine/ brain metastases/ magnetic resonance imaging分类
医药卫生引用本文复制引用
王庆军,王勇,徐贤,肖慧,马林..钆贝葡胺和钆喷酸葡胺在磁共振增强扫描诊断单发脑转移瘤中照研究[J].南方医科大学学报,2011,31(12):1968-1973,6.基金项目
国家自然科学基金(30970816) （30970816）
