南方医科大学学报2011，Vol.31Issue(12)：2006-2011,6.DOI:44-1627/R.20111206.1505.003
小口径聚氨酯人工血管的制备及其力学性能、细胞相容性评价
Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis
摘要
Abstract
Objective To develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility. Methods The effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber (4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties. The mechanical properties and biocompatibility of the prepared grafts were evaluated. Results The polyurethane vascular grafts showed a three-dimensional reticular structure consisting of nanofibers, with an average porosity of (51.48±4.47)% and tensile strength of 5.85 ± 0.62 Mpa. The grafts provided a better long-term support than e-PTFE graft for endothelial cell growth and endothelialization. Conclusion The polyurethane vascular prosthesis possessed favorable microstructures, excellent mechanical properties and good biocompatibility for potential clinical application.关键词
人工血管/聚氨酯/电纺/力学性能/生物相容性Key words
vascular prosthesis/ polyurethane/ electrospinning/ mechanical performance/ biocompatibility分类
医药卫生引用本文复制引用
贺薇,胡作军,徐安武,受恒讳,王劲松,叶洁莲,王深明..小口径聚氨酯人工血管的制备及其力学性能、细胞相容性评价[J].南方医科大学学报,2011,31(12):2006-2011,6.基金项目
国家"863"项目(2007AA021904) （2007AA021904）
广东省科技计划项目(2011B031300002,2010B031600055) （2011B031300002,2010B031600055）
