癌症（英文版）2012，Vol.31Issue(2)：58-72,15.DOI:10.5732/cjc.011.10329
Multidrug resistance associated proteins in multidrug resistance
Multidrug resistance associated proteins in multidrug resistance
摘要
Abstract
Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters.These ABC transporters together form the largest branch of proteins within the human body.The MRP family comprises of 13 members,of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the cell.They are mainly lipophilic anionic transporters and are reported to transport free or conjugates of glutathione (GSH),glucuronate,or sulphate.In addition,MRP1 to MRP3 can transport neutral organic drugs in free form in the presence of free GSH.Collectively,MRPs can transport drugs that differ structurally and mechanistically,including natural anticancer drugs,nucleoside analogs,antimetabolites,and tyrosine kinase inhibitors.Many of these MRPs transport physiologically important anions such as leukotriene C4,bilirubin glucuronide,and cyclic nucleotides.This review focuses mainly on the physiological functions,cellular resistance characteristics,and probable in vivo role of MRP1 to MRP9.关键词
Multidrug resistance protein (MRP)/multidrug resistance (MDR)/ABC transporter/chemotherapyKey words
Multidrug resistance protein (MRP)/multidrug resistance (MDR)/ABC transporter/chemotherapy引用本文复制引用
Kamlesh Sodani,Atish Patel,Rishil J. Kathawala,Zhe-Sheng Chen..Multidrug resistance associated proteins in multidrug resistance[J].癌症（英文版）,2012,31(2):58-72,15.基金项目
This work was supported in part by grants from NIH R15 No.1R15CA143701 (to Z.S.Chen) and St.John's University Seed Grant No.579-1110-7002 (Z.S.Chen).K.Sodani and A.Patel thank the Teaching fellowship from Department of Pharmaceutical Sciences,College of Pharmacy and Allied Health Professions,St.John's University. （to Z.S.Chen）
